Posts from ‘Paralysis’

Anthony Russell, a professor at the University of Calgary, and his colleague, Tim Higham from Clemson University in South Carolina, observed movement in gecko tails after they were severed and were inspired to explore possible ramifications and applications to humans paralyzed by complete spinal cord injuries. The professors noted that there is a great similarity between the neural cells in gecko tails and neural cells in human tailbones. Complete spinal cord injuries refer to injuries in which the spinal cord has been completely severed.
Russell noted in the article that the severed gecko tails moved somehow without physical connection or communication from the brain. He was quoted as saying, “Something in the tail is saying to the tail, ‘Lets use this muscle to move a lot, then take a break, then move again.’ ”
He speculated that the movement in the tail arises as a response to environmental stimuli such as temperature or pressure, which elicit a response in the muscles without prompting from the brain. Humans also reportedly experience movements in their paralyzed limbs after spinal cord injuries.
Other studies released last week reported that rats with severed spinal cords were able to walk on treadmills and support their own weight after a combination treatment of drugs administered below the spinal cord injury, locomotor training, and electrical stimulation.
The movement in severed gecko tails could hold further secrets behind how movement can occur without direct communication from the brain. These studies move scientists and doctors ever closer to a cure for paralysis. The basic implication of the rats studies and gecko observations is the hypothesis that movement is not completely dependent on messages from the brain.
The two professors, Russell and Higham, hope to inspire and collaborate with doctors and scientists on potential research into spinal cord injury applications of their knowledge and observations.
Integration between observations of various professors and scientists with research data and knowledge gathered by surgeons and researchers holds a potential key toward medical advances far beyond the prospects and possibilities presented in singular isolated studies. Integrated thinking across disciplines may lead to more holistic approaches to research and disease prevention, and give realistic hope to those currently suffering from irreversible paralysis.
(pic from herper.com/)
Scientists at the David Geffen School of Medicine at UCLA and researchers from the University of Zurich in Switzerland have discovered stunning information on how nerves in the spinal cord, even in cases of paralysis, can be stimulated to elicit a walking response, without communication between the brain and the nerves. The researchers used a combination of treatments to enable rats with severed spinal nerves to bear the full weight of their bodies and run for up to 30 minutes.
The treatment consisted of drugs known as serotonergic agonists, electrical stimulation applied to nerves below the spinal cord injury, and rehabilitation on a slow moving treadmill. When the nerves were activated with electrical currents, it activated evolutionarily primitive nerve connections in the spinal cord to elicit movement in the rats’ limbs without information from the brain.
At first, the rats were only able to move their back legs for a small amount of time. Over a week, the rats could run and walk without support. After a few weeks, the rats were able to fully support their own weight and run forward, backward, and sideways for up to 30 minutes. However, the rats remained dependent on the mix of drugs and electrical stimulation to make their legs work.
Researchers from the University of Zurich also reported that they are developing a series of electrodes for insertion along the spinal cord. They expect to begin human trials in about four years.
Previously, scientists have been able to generate movement in the legs of paralyzed human subjects in the past. Until the most recent study, published in the most recent online edition of Nature Neuroscience, they had never been able to elicit continuous walking and full weight bearing in the paralyzed rats.
The Christopher and Dana Reeve Foundation and many other contributors funded the study. Scientists and support foundations hope to inspire further research leading to a cure for paralysis for patients with severe spinal cord injuries. One of the most remarkable implications of the study is that, “nerve fibers do not need to regrow in order for a paralyzed patient to walk again.”
Combined with neuroprosthetic devices, which may allow a communication bridge from the brain across the injured spinal cord, the data from the current study has brought scientists one step closer to finding a cure for paralysis.
(pic from cdn-write.demandstudios.com)

Peter Wildetrotter, President and CEO of the Christopher and Dana Reeve Foundation, sent a letter to brainandspinalcord.org to show his appreciation and to share with our readers some of the recent breakthroughs in spinal cord injury and brain injury research. The Reeve Foundation funds projects dedicated to finding a cure for paralysis.
The letter brings up many important discoveries and advances, including a recent experiment on rats with severed spinal cords. The rats were able to walk again after a complex, three-part treatment. The rats had completely severed spinal cords. They were given a dose of the drug quipazine, electrical stimulation below the spinal cord injury site, and then locomotor training.
Surprisingly, the rats were able to walk on treadmills while fully supporting their own weight. Previous to this experiment, it was widely believed that movement was impossible below the site of severed spinal cord. Wildetrotter added that the physical movements of the rats was nearly identical to their walking motions before their spinal cord injury.
Even more importantly, the study proves that movement is still possible even when the line of communication between the brain and spinal cord is severed. In order to make such advanced studies possible, many forces must harmonize and collaborate with one another. New research often must confront dated and obsolete ways of thinking, and it is the determination and hard work of countless scientists, universities and medical facilities, public and private funding sources like the Reeve Foundation, and sites such as this one that are necessary to make the formerly impossible possible.
It is not only the scientists and foundations that make a difference, it is every individual who donates time, energy, and money toward paralysis research. Wildetrotter wrote of the recent paralysis breakthrough, “Every time you and other Reeve Foundation supporters donated your hard earned money, contacted your Congressperson or Senator to fund paralysis research, participated in a Team Reeve event, attended a comedy night or other event, you helped make this happen.”
He also expressed gratitude for the public and private support that make possible the Reeve Foundation’s International Research Consortium, as well as the NeuroRecovery network, where spinal cord injury survivors receive locomotor training.
Wildetrotter concluded his letter with a promise to continue the Reeve Foundation’s noble efforts toward a cure for paralysis and expressed enthusiasm that, “Science is fulfilling Christopher’s vision.”
You can donate to the cause by visiting the Reeve Foundation’s website: www.christopherreeve.org/
Brain and spinal cord injuries are two common results of automobile accidents. A large number of lawsuits have been filed against General Motors by persons suffering from brain and spinal cord injuries sustained in accidents involving defective GM vehicles or parts, and many of those cases are currently pending. On June 1, 2009, GM filed for protection from creditors in the Bankruptcy Court for the Southern District of New York, resulting in all pending lawsuits being stayed until the bankruptcy is finalized. The case was assigned to Judge Robert E. Gerber who is holding hearings on GM’s proposed reorganization at the time of this post.

One of the issues Judge Gerber is expected to rule on this week is whether persons injured by defective GM products will retain their rights to sue or continue lawsuits pending against GM. There are three categories of injured people whose rights will be affected by the Court’s rulings. The first are people who had filed lawsuits against GM and received judgments prior to the bankruptcy, but had not yet been paid. These people are considered unsecured creditors of GM. The second category are those who were injured by GM products and filed lawsuits that were not resolved before the bankruptcy, so their claims are pending subject to the stay. The final group, are those who will be injured in the future by GM products sold before bankruptcy. Under pressure from consumer groups and Attorney’s General from more than ten states, , GM agreed in negotiations leading up to this week’s hearings to allow people injured by GM products in the future to retain their rights to sue. GM has not, however, capitulated on recognizing pending claims and judgments.
An example of the types of claims that would be extinguished if the court approves GM’s proposed plan is the claims of four year old Alyssa Perrino. Alyssa was a healthy, intelligent little girl who sustained catastrophic brain injuries requiring removal of a large portion of her skull when a weak seat in the GM vehicle in which she was riding failed rearward and struck her head. At the time of the accident, Alyssa was properly strapped into her car seat in the rear of the vehicle. Prior to the accident, Alyssa spoke three languages, but as a result of her brain injuries, she is now only able to speak ten to fifteen words. Her mobility is severely limited. Alyssa was lucky to survive the accident, but her life and the life of the Perrino family has been forever changed. While the Perrino family’s lawsuit against GM was resolved prior to GM’s bankruptcy, it is typical of cases in which defective vehicles caused irreversible brain and spinal cord injuries.
The bankruptcy plan proposed by GM would transfer automotive brands Chevrolet, Cadillac, Buick and GMC to a new company called Vehicle Acquisition Holdings LLC (Newco). Under the plan, the United States Government would own 60 percent of Newco, the Canadian government would get 12.5 percent, the United Auto Workers Union, 17.5 percent and unsecured creditors, 10 percent. Existing GM shareholders are not expected to receive any interest in Newco. Technically, People whose lawsuits the bankruptcy court does not extinguish will proceed against Newco. Those lawsuits that do not survive the bankruptcy can continue against the “old GM”, but the old GM is not expected to have assets to pay claims even it the lawsuits were successful.
While the proposed reorganization plan submitted by General Motors, would extinguish claims for injuries like Alyssa Perrino’s if they were pending at the time the bankruptcy was filed, ironically, GM has agreed that the new owner of GM would assume GM’s liability for warranty claims. Thus, approval of the plan would lead to the illogical result that if a GM part fails under warranty, the new GM would be liable for the repair, but if the same part killed or injured a person prior to the bankruptcy, the new GM would have no liability at all.
On June 19, 2009, the deadline for filing objections to the proposed GM sale, consumer groups, unions and creditors filed objections to the GM bailout. Philadelphia attorney Barry Bessler is represented a number of consumer groups in the Chrysler bankruptcy and is representing them in the GM proceedings, as well. During the Chrysler proceedings, Chrysler successfully washed its hands of all past and future product liability claims involving Chrysler products sold prior to the bankruptcy. Bressler had argued that the GM case is distinguishable from the Chrysler case in terms of the proper way to treat product liability claimants. Bressler was quoted in Law.Com as saying “[i]n GM, there is no third-party buyer. Hopefully, that means there’s a stronger case [for successor liability].” Attorneys for people with pending asbestos products liability lawsuits against GM, have filed objections to the proposed plan, as well.
In addition to consumer groups, attorneys general from at least eleven states filed objections to the “no successor liability” provisions of the bankruptcy plan proposed by GM. Attorneys general from Connecticut, Kentucky, Maryland, Minnesota, Missouri, Nebraska, North Dakota, Montana, Ohio, West Virginia and Vermont filed objections arguing that GM’s plan to extinguish liabilities for injuries cased by safety defects would take key legal rights away from victims. Attorney General Richard Blumenthal of Connecticut referred to GM’s proposal as “very unfair and unwise “. In an interview, Blumenthal stated “[s]o much is at stake. We have fought repeatedly for repair or recall of vehicles and parts that are defective so that people can be spared injury, and there are far-reaching ramifications of failing to apply accountability to the New GM.”
Attorneys general from a number of states also filed objections to GM’s proposed plan due to the impact it would have on GM dealers in their states. In his statement regarding Montana’s objections to the GM proposal, Montana’s Attorney General Steve Bullock said that GM is attempting to circumvent state laws designed to protect auto dealers. According to Bullock, GM has insisted that current GM dealers sign new dealership agreements that force these dealers to waive state laws that were enacted to protect them. Bullock further stated that, if his state lost dealerships, some consumers in rural areas would have to drive hundreds of miles just to get their cars or trucks serviced.
In addition to objections on behalf of consumers and dealers, objections to the GM restructuring were also filed by various bondholders who argued that they were treated unfairly vis a vis other creditors. Finally, the Steelworkers Union filed objections on behalf of retired steelworkers and engineers who said the plan would leave GM without funds to pay health benefits to union-represented retirees and their families. In their objections, the Steelworkers and Engineers said that “GM has been not only unfair, but cruel” in its treatment of the steelworkers and engineers, and that GM was attempting to renege on a deal to create a health care trust for current workers and to protect the health and life insurance benefits of retirees.
A multi-day hearing on GM’s proposed sale began June 30, 2009 . At the time this article was posted, proceedings were ongoing and Judge Gerber had not ruled on the objections of injured consumers. Persons interested in following the proceedings in near real time can do so at http://dealbook.blogs.nytimes.com.
The outcome of the negotiations and court proceedings will affect many people who stand to lose jobs, benefits or investments, but none will be more profoundly affected than persons who have suffered catastrophic injuries such as brain and spinal cord injuries caused by defective GM products. With many millions of GM vehicles on U.S. roads, it is impossible to estimate the number of people who will be injured, and lack the resources to obtain essential medical and other services. Given that many of these people will become medical wards of the States, U.S. taxpayers will continue bailing out and GM and Chrysler long after the astounding infusion of public funds during the current bankruptcy proceedings has been forgotten.
Up until this month, the general consensus estimated the amount at 250,000 and about four million, respectively. Large numbers indeed, but according to a study just released by the Christopher & Dana Reeve Foundation, they fall far short of reality.
Add 40% to the number of those living with paralysis and multiply four million spinal cord injuries by five and you will have a better idea of the actual numbers: 1.275 million spinal cord injuries and 5.6 million who live with some kind of paralysis.
The study (that surveyed more than 33,000 households) was simplified by the president and CEO of the Reeve Foundation to mean “one in 50 Americans is living with some form of paralysis, whether caused by disease, spinal cord injury or neurological damage…someone you know is living with paralysis – a family member, a friend or a work colleague”.
Some key findings:
- Paralysis and spinal cord injuries are a great deal more widespread than previously assumed.
- Stroke, followed by spinal cord injuries are the top causes of paralysis.
- “Household income for those with paralysis is heavily skewed towards lower-income brackets and is significantly lower than household income for the country as a whole. Roughly 25 percent of households with a person who is paralyzed earn less than $10,000 per year, compared with only seven percent of households in the general population.”
This survey is the first of its kind and the data that it collected will help this population obtain the health care that they need. In response to this study, the Reeve Foundation plans to launch a campaign to change public policy for the better – stay tuned for more details!
Over the last couple of years we have been hearing of the push to digitize health records, in hopes of streamlining a patients data for easy access across medical facilities. Yesterday the Mayo clinic announced a partnership with Microsoft’s HealthVault to launch the Mayo Clinic Health Manager, a tool that gives people the ability to store their medical records online as well as sign up for alerts and reminders. This is only the latest in a procession of new online storage services being offered to interested patients.
Using these services you can import your health records from your doctors, hospitals, labs, prescription drug plans, and other healthcare providers by typing them in yourself or uploading data directly from devices such as blood-pressure monitors. Now with just a couple clicks of your mouse, you can view your entire medical history – what medications you have taken, which ones you are currently on, adverse reactions, operations, diagnosis, and even childhood diseases. What’s online is up to you and, if he is a participant in the government supported push for electronic records, your doctor.

We aren’t going to advocate for or against the digitizing of your healthcare history, but we do want to make sure you are taking into consideration the potential dangers of such a move. While the convenience of hopping online to find out what date you started a particular medication may make the process of filling out your insurance claim easier, keep in mind that what’s easy access for you is just as easy for someone else. Yes, we are talking about hackers. Those information pirates that keep developing more and more insidious data-mining processes.
What does it matter if some stranger is copying your medical information? What can it hurt besides your feelings of privacy? A lot, actually.It isn’t just insurance claims that are affected by your medical history, your reputation is also potentially at risk.
M. Eric Johnson, director of the Glassmeyer/McNamee Center for Digital Strategies at Dartmouth’s Tuck School of Business, released a paper in which he said he and his fellow researchers “were able to uncover a number of medical records and other files with medical information online, using file-sharing services generally associated with song-swapping, like LimeWire and Kazaa”. He went on to note that many of our records are already in electronic form on computers in small clinics and laboratories whose security can’t begin to match that offered by the larger data storage facilities.
Johnson cites numerous instances of leaked records leading to identity theft, medical insurance fraud, and even financial fraud. Don’t forget, your social security number is more often than not is included in your medical records, and adding that information to identifying data such as your date of birth, address, and full name give thieves everything they need to make a profit from your information.
When you are considering making your records electronic, make sure you choose a company that has multiple safeguards in place. While there are always ways around even the toughest Internet security, the likelihood of keeping your information private greatly increases depending what program provider you go with. Google Health has partnered with Medco, as Microsoft’s HealthVault has teamed up with the Mayo Clinic, giving the resulting storage systems more clout than lesser known companies such as iHealthRecord or myPHR, but before you make a choice, research them well – your private data is on the line!
Image from here.
We’d like to share some updated information on the Christopher & Dana Reeve Paralysis Act with you:
“Your voice can help take the Christopher & Dana Reeve Paralysis Act across the finish line. Last month, the CDRPA was inserted into a large bill containing many environmental bills, called the Omnibus Public Land Management Act (S.22). The vast majority of these bills have little to no opposition, strong local supporters and broad, bi-partisan support in Congress, just like the CDRPA. They were packaged together because most of them were blocked by Senatorial holds.
There are several different types of insurance that will cover you and your loved ones in the event of a brain or spinal cord injury. These are Personal Injury and Liability insurance, Uninsured Motorist insurance, Worker’s Compensation, health and accident insurance, and short- and long-term disability…

Lauren Barkwick, a former worker at an elite horse ranch known for providing horses for movies and television in Canada, learned an extremely tough lesson about the value of life and freedom of movement. Barwick had competed with and defeated other applicants to land an internship at the Mission, British Columbia studio ranch. She was only a week into her new job when she had a catastrophic accident that left her irreversibly 
