We are always looking for new developments that can lead to spinal cord injury (SCI) recovery and press releases like this one are a great incentive to keep looking.

The PLoS Medicine site reports that researchers studying spinal cord injuries in mice found that chondroitin sulfate proteoglycan (CSPG) is needed for the repair of the neurons that will facilitate the regaining of movement, but after time, it actually hinders a full nervous system recovery. In studies on mice, the researchers allowed CSPG to act uninhibited for two days after the injury before interfering and by doing this, created a promising response in the animals.

Heavily secreted after an injury, CSPG helps to form glial scars after a SCI. These scars protect the damaged areas, but they also release chemicals that work to prevent further regeneration in the nervous system. Because of its link to preventing axonal development, researchers were focused on eliminating CSPG from the injured area.

This compounded data suggests that eliminating CSPG may not be the best answer, and scientists are opting instead to control it. CSPG has a place in the healing process as it regulates the local immune response which is vital for proper healing.

So far studies only extend to animals, not humans, but there are similar enough correlations between spinal cord repair processes that it’s believed this research can soon be applied to human subjects.

To read the original release, please click here.

Four men are “wheeling” across Canada with the use of hand cycles in order to bring awareness and generate donations to research for conditions such as concussive head injury and Alzheimer’s. They believe that a donation of 30 cents by each Canadian citizen for “breakthrough” research will allow them to walk again.

This research comes from a Canadian research team at McMaster University in Hamilton. Dr. Michel Rathbone and Dr. Shucui Jiang successfully regenerated nerves in the chronically damaged spinal cords of rats with the use of adult enteric glia cells. These cells are abundant in human and animal intestines and have been found to support the nervous system.

The enteric glia cells were grown in cell cultures and then transplanted into the rat’s spinal cords where they stimulated nerves to grow, reducing the damage in the spinal cord. These cells are not only stable, they have bypassed the problem of tissue rejection by the host. In addition, this team of scientists found that a naturally occurring molecule in the body, guanosine, stimulates stem cells already present in the spinal cord to grow and develop into cells that insulate the nerve processes.

Even more interesting, this medical approach and application can be used on other diseases as well, including those of the brain.

To progress beyond animal testing, the researchers need support. You don’t have to be Canadian to pitch it - visit Wheel to Walk for more information!